Specifically, ketamine produced a large degree of anti-SI effect within the 4– 6 hours (Cohen’s d = 1.16, 95% CI: 0.50, 1.81) and a medium-large degree in the 24 hours (Cohen’s d = 0.95, 95% CI: 0.48, 1.41). Results: Our study showed that intravenous sub-anesthetic doses of ketamine and intranasal inhaled esketamine had a significant anti-SI effect. ![]() To obtain effect sizes (Cohen’s d), we calculated the difference in Suicide Scale scores before and after administration in each group. Our primary outcome measure was the Suicide Scale score, which was measured using the Scale for Suicidal Ideation (SSI), Beck Scale for Suicide Ideation (BSS), Beck Depression Inventory (BDI), or Modified Scale for Suicidal Ideation (MSSI). Study Eligibility Criteria: We conducted a systematic review of all parallel randomized controlled trials (RCTs) examining the effect and duration of ketamine or esketamine on SI. We conducted a meta-analysis to evaluate the efficacy of ketamine and esketamine in reducing suicidal ideation (SI), as well as their respective onset and duration of action.ĭata Sources: We searched PubMed, Embase, Ovid, Cochrane, and Web of Science databases for studies published from inception to September 29, 2022. ![]() Preliminary evidence suggests that intravenous ketamine has rapid and sustained antidepressant effects, making it a candidate with therapeutic potential for depressed patients at risk for suicide. Purpose: Suicide is a major public health concern with currently no validated and efficacious treatments approved. *These authors contributed equally to this workĬorrespondence: Xiao-Bin Wang, Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People’s Republic of China, Tel +86 13708280087, Fax +86 830-3161222, Email Cheng-Chuan Chen, 1, * Na Zhou, 2, * Na Hu, 1 Jian-Guo Feng, 1 Xiao-Bin Wang 1ġDepartment of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People’s Republic of China 2School of Nursing, Southwest Medical University, Luzhou, People’s Republic of China
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